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  7. 12820510

Cyclin A Mouse anti-Human, Unlabeled, Clone: 25, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 611268

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Codice prodotto. 12820510

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Descrizione

Descrizione

Progression of the mammalian cell cycle is regulated by phosphorylation of many key proteins. Several classes of cyclins (A-E) act as regulatory subunits for cyclin-dependent kinases (cdks). These cyclin-cdk holoenzymes are essential for proper control of cell cycle progression. They phosphorylate and regulate a variety of substrates whose activity is required for cell cycle transitions. The temporal expression of cyclins is tightly regulated throughout the cell cycle by synthesis and degradation. Such regulation plays a critical role in controlling the enzymatic activity of the cdks. Cyclin A, one of the mitotic cyclins, activates Cdk2 near the start of S phase and is necessary for the initiation of DNA replication. In mammalian somatic cells, Cyclin A is required during S phase and passage through G2. The D and E type cyclins regulate passage through G1, while Cyclin B is a critical regulator of mitosis. It has been shown in a number of species that mutation or disruption of normal Cyclin A expression causes cells to arrest at G2. Cyclin A binds both the cdc2 (Cdk1) and Cdk2 kinases and may also have a role in mitotic dependence on S phase completion.

Host Species: Mouse
Clone: 25
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Cyclin A aa. 26-144
Formula Weight [Chemical]: 60kDa

Bioimaging, Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY
Specifica

Specifica

Cyclin A
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human Cyclin A aa. 26-144
50 μg
Cell Biology
Human
IgG1
Western Blot
25
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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