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Cyclin A Mouse anti-Human, Unlabeled, Clone: 25, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 611269
383.06 EUR valido fino al 2025-12-31
Usa il codice promo "25339" per avere il tuo prezzo promozionale.
Descrizione
Progression of the mammalian cell cycle is regulated by phosphorylation of many key proteins. Several classes of cyclins (A-E) act as regulatory subunits for cyclin-dependent kinases (cdks). These cyclin-cdk holoenzymes are essential for proper control of cell cycle progression. They phosphorylate and regulate a variety of substrates whose activity is required for cell cycle transitions. The temporal expression of cyclins is tightly regulated throughout the cell cycle by synthesis and degradation. Such regulation plays a critical role in controlling the enzymatic activity of the cdks. Cyclin A, one of the mitotic cyclins, activates Cdk2 near the start of S phase and is necessary for the initiation of DNA replication. In mammalian somatic cells, Cyclin A is required during S phase and passage through G2. The D and E type cyclins regulate passage through G1, while Cyclin B is a critical regulator of mitosis. It has been shown in a number of species that mutation or disruption of normal Cyclin A expression causes cells to arrest at G2. Cyclin A binds both the cdc2 (Cdk1) and Cdk2 kinases and may also have a role in mitotic dependence on S phase completion.
Host Species: Mouse
Clone: 25
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Cyclin A aa. 26-144
Formula Weight [Chemical]: 60kDa
Bioimaging, Immunofluorescence, Western Blotting
Specifica
Cyclin A | |
Monoclonal | |
250μg/mL | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Human Cyclin A aa. 26-144 | |
150 μg | |
Cell Biology | |
Human | |
IgG1 |
Western Blot | |
25 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
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