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Bleomycin sulfate, Thermo Scientific Chemicals
Descrizione
Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
- It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
- Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation
Application
- It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
- Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
- Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
- In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice
Specifica
Specifica
| Materiale o nome chimico | Bleomycin sulfate |
| Tipo | Bleomycin Sulfate |
| Forma fisica | Powder |
| Colore | White |
| Quantità | 10 mg |
| Indice di Merck | 14,1318 |
| Informazioni di solubilità | Soluble in water or DMSO |
Sicurezza e movimentazione
- Bleomycin sulfate
- Pericolo
- cancerogenicità Categoria 2
- Mutagenicità di cellule germinali Categoria 1B
- Tossicità per la riproduzione Categoria 2
- H340-Può provocare alterazioni genetiche.
- H351-Sospettato di provocare il cancro.
- H361d-Sospettato di nuocere al feto.
- P201-Procurarsi istruzioni specifiche prima dell'uso.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
- MIXTURE LIST-Contiene: Bleomycin, sulfate (salt)
RUO – Research Use Only
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