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  6. CD154 Mouse anti-Human, FITC, Clone: TRAP1, BD

CD154 Mouse anti-Human, FITC, Clone: TRAP1, BD

Mouse Monoclonal Antibody

475.08€

Specifica

Antigene CD154
Clone TRAP1
Applicazioni Flow Cytometry
Classificazione Monoclonal
Coniugato FITC
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Prodotti 1
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
10081934
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BD Biosciences
555699 		100 Tests
ONLINE EXCLUSIVE PRICE
476.00€
475.08€ / Pezzo
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Descrizione

Descrizione

The TRAP1 monoclonal antibody specifically binds to CD154. CD154 is a 39 kDa type II membrane glycoprotein that is a member of the tumor necrosis factor superfamily, Tumor necrosis factor ligand superfamily member 5 (TNFSF5). CD154 is expressed on a variety of cell types including activated CD4+ T cells and some CD8+ T cells, NK cells, mast cells and basophils. CD154 is also known as CD40 ligand (CD40L); it serves as a ligand for CD40 that is expressed on B cells, macrophages, and dendritic cells. The expression of CD154 by activated T-helper cells costimulates B-cell activation and proliferation through binding to CD40 expressed on B cells. In response to T-dependent antigens, the CD154 and CD40 interaction is required for B-lymphocyte differentiation, including immunoglobulin production and isotype switching and memory B cell generation. The TRAP1 antibody can partially block T cell-B cell interaction and inhibit the subsequent proliferation, differentiation, and memory formation of B cells. It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD154 due to mutations in the CD40LG gene that encodes CD154.

Specifica

Specifica

CD154
Flow Cytometry
FITC
RUO
Baboon, Cynomolgus, Human, Rhesus Monkey
IgG1 κ
Affinity Purified
CD40LG; CD40 ligand; CD40L; TNFSF5; T-BAM; TRAP
TRAP1
Monoclonal
Mouse
Immunology
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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