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Cytarabine, 98%, Thermo Scientific Chemicals

Codice prodotto. 15244774
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Quantità:
100 mg
1 g
5 g
Imballaggio:
Glass bottle
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
Cytarabine is a nucleoside analog that acts as an antileukemic agent
Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells
Applications
Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
Useful for laboratory studies of cytarabine resistance mechanisms
At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 147-94-4
Formula molecolare C9H13N3O5
Molecular Weight (g/mol) 243.22
InChI Key UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Sinonimo cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine
PubChem CID 6253
ChEBI CHEBI:28680
IUPAC Name 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

Specifica

Materiale o nome chimico Cytarabine
Punto di fusione 220.0°C
Intervallo percentuale saggio 97.5% min. (HPLC)
Imballaggio Glass bottle
Quantità 100 mg
Indice di Merck 152781
Informazioni di solubilità Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol
Peso formulazione 243.22
Percent Purity 98%

Sicurezza e movimentazione

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Identificativo prodotto
  • Cytosine beta-D-arabinofuranoside
 Avvertenza
  • Attenzione
 Categoria di pericolo
  • Lesione oculare grave/irritazione oculare Categoria 2
  • Tossicità per la riproduzione Categoria 2
  • Sensibilizzante delle vie respiratorie Categoria 1
 Indicazioni di pericolo
  • H317-Può provocare una reazione allergica cutanea.
  • H361d-Sospettato di nuocere al feto.
  • H319-Provoca grave irritazione oculare.
 Consigli di prudenza
  • P201-Procurarsi istruzioni specifiche prima dell'uso.
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P305+P351+P338-IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.

RUO – Research Use Only

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