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  8. GNF 5837, Tocris Bioscience™

GNF 5837, Tocris Bioscience™

Codice prodotto. 30001587
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Quantità:
10 mg
50 mg
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

Identificatori chimici

CAS 1033769-28-6
Formula molecolare C28H21F4N5O2
Molecular Weight (g/mol) 535.50
Numero MDL MFCD24386809
InChI Key YYDUWLSETXNJJT-UHFFFAOYSA-N
Sinonimo z-1-3-3-1h-pyrrol-2-yl methylene-2-oxoindolin-6-yl amino-4-methylphenyl-3-2-fluoro-5-trifluoromethyl phenyl urea, 1-2-fluoro-5-trifluoromethyl phenyl-3-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea, d02rwc, n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl urea, 2-2-2-methoxy-4-4-morpholinyl phenyl amino-5-trifluoromethyl-4-pyridinyl amino-n-methylbenzamide, 3-2-fluoro-5-trifluoromethyl phenyl-1-4-methyl-3-3z-2-oxo-3-1h-pyrrol-2-ylmethylidene-1h-indol-6-yl amino phenyl urea, n-3-2,3-dihydro-2-oxo-3-1h-pyrrol-2-ylmethylene-1h-indol-6-yl amino-4-methylphenyl-n'-2-fluoro-5-trifluoromethyl phenyl-urea
PubChem CID 59397065
IUPAC Name 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-({2-oxo-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-6-yl}amino)phenyl]urea
SMILES CC1=C(NC2=CC3=C(C=C2)C(=CC2=CC=CN2)C(=O)N3)C=C(NC(=O)NC2=C(F)C=CC(=C2)C(F)(F)F)C=C1

Specifica

Materiale o nome chimico GNF 5837
Quantità 10 mg
Peso formulazione 535.49
Percent Purity >98%
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