GTF3A Polyclonal Antibody, Invitrogen™

Descrizione

Immunogen sequence: KRKDYLKQHM KTHAPERDVC RCPREGCGRT YTTVFNLQSH ILSFHEESRP FVCEHAGCGK TFAMKQSLTR HAVVHDPDKK KMKLKVKKSR EKRSLASHLS GYIPPKRKQG QGLSLCQNGE SPNCVEDKML STV Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 77%.

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.