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Tocris Bioscience™ HER2 PROTAC™ CH7C4
Potent and selective HER2 targeting PROTAC™
Marca: Tocris Bioscience™ 7886/5
343.51 EUR valido fino al 2024-12-16
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Descrizione
HER2 PROTAC™ CH7C4 is a potent and selective HER2 (also called ErbB-2) targeting PROTAC™ (DC50 = 69 nM; Dmax = 96%). Inhibits BT-474 cell proliferation (IC50 = 47 nM) and xenograft growth. Comprises a Tucatinib (Cat. No. 7640) analog, joined by a linker to a CRBN E3 ligase ligand. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.Specifica
| 5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | |
| Active Degraders | |
| 98% |
| 5 mg | |
| C49H55N11O7 |