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ACROBiosystems Human CD3 gamma / CD3G Protein, Fc Tag (MALS verified)
457.25€ - 3357.52€
Specifica
Numero di accesso | AAI13831.1 |
---|---|
Peso molecolare | 37.1 kDa |
Sorgente | Human CD3 gamma, Fc Tag (CDA-H5254) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Ser 116 (Accession # P09693-1). |
Immunogeno | Gln 23 - Ser 116 |
Requisiti di stoccaggio | -20°C |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
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Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
17266120
|
ACROBiosystems
CDA-H5254-100UG |
100 μg |
457.25€
100µg |
Spedizione stimata: 07-08-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
17276120
|
ACROBiosystems
CDA-H5254-1MG |
1 mg |
3357.52€
1mg |
Spedizione stimata: 07-08-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
Descrizione
CD3 gamma chain is part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
AAI13831.1 | |
Human CD3 gamma, Fc Tag (CDA-H5254) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Ser 116 (Accession # P09693-1). | |
-20°C | |
CD3 gamma | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers & CD Antigens |
37.1 kDa | |
Gln 23 - Ser 116 | |
CD3G,CD3-GAMMA,IMD17,T3G,TCR gamma | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE. |