Macherey-Nagel™ LIPODEX™ A Capillary Columns for GC

A major advantage of LIPODEX columns are that many compounds can be analyzed without derivatization. However, for certain substances, enantioselectivity can be favorably influenced by formation of derivatives. Regioselective alkylation and/or acylation of the hydroxyl groups leads to lipophilic phases with varying enantioselectivity, which are well suited for GC enantiomer analyses.

It is not possible to make a general prediction about which LIPODEX™ phase could solve a given separation task. Even for compounds with small structural differences or within homologous series, the enantiodifferentiation can be quite different.

• Base material: cyclic oligosaccharides consisting of six α-cyclodextrin glucose units bonded through α-1,4-linkages
• hexakis-(2,3,6-tri-O-pentyl)- α-cyclodextrin
• Ligands: R2=R3=R6=pentyl; n=1
• Recommended for carbohydrates, polyols, diols, hydroxycarboxylic acid esters, (epoxy‑) alcohols, glycerol derivatives, spiroacetals, ketones, alkyl halides