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Invitrogen™ Mouse Leptin R ELISA Kit

Mouse Leptin R quantitates mouse Leptin R in serum, plasma, supernatant.

Marca:  Invitrogen™ EM48RB

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Codice prodotto. 16634914

  • 642.00€ / Pezzo
Spedizione stimata: 10-12-2024
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Descrizione

Descrizione

Mouse Leptin R quantitates mouse Leptin R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Leptin R.

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
TRUSTED_SUSTAINABILITY
Specifica

Specifica

B219; CD antigen CD295; CD295; CD295 antigen; db; diabetes; Fa; HuB219; HuB219.2; LEPR; LEP-R; Leprb; LEPRD; LEPROT; Leptin receptor; Leptin receptor (fatty); leptin receptor gene-related protein; Modb1; OB receptor; obese-like; obl; Obr; OB-R; OB-RGRP
32 pg/mL
ELISA
Colorimetric Microplate Reader
Lepr
<10%
HRP
Research Use Only
2°C to 8°C
1 hr 20 min
32 to 8,000 pg/mL
Biotin
Plasma, Serum, Supernatant
P48356
<12%
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
96 Tests
Serum, 50 μL; Plasma, 50 μL; Supernatant, 50 μL
Leptin Receptor
4 hr 45 min
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