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Tocris Bioscience™ Phototrexate
Photoswitchable inhibitor of human dihydrofolate reductase
Marca: Tocris Bioscience™ 7362/5
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Descrizione
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate (Cat. No. 1230). Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark. cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared with trans-Phototrexate (IC50 = 34 μM).Specifica
| N-[4-[(1 E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid | |
| 5 mg | |
| C20H19N7O5 |
| 2268033-83-4 | |
| Dihydrofolate Reductase Inhibitors | |
| 95% |