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Purmorphamine, Tocris Bioscience™

Codice prodotto. 30002010
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Quantità:
10 mg
50 mg
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

Smo receptor agonist

Purmorphamine is a smoothened (Smo) receptor agonist (EC50 ∼ 1 μM) and activates the Hedgehog pathway. Purmorphamine induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, Purmorphamine can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Purmorphamine induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts, and of spinal motor neurons from pluripotent human stem cells, and protects dopaminergic neurons in a mouse model of Parkinson's disease.

Identificatori chimici

CAS 483367-10-8
Formula molecolare C31H32N6O2
Molecular Weight (g/mol) 520.637
InChI Key FYBHCRQFSFYWPY-UHFFFAOYSA-N
Sinonimo purmorphamine, 2-1-naphthoxy-6-4-morpholinoanilino-9-cyclohexylpurine, unii-pb12m2f8ky, shh signaling antagonist vi, pb12m2f8ky, 9-cyclohexyl-n-4-morpholin-4-yl phenyl-2-naphthalen-1-yloxy-9h-purin-6-amine, 9-cyclohexyl-n-4-4-morpholinyl phenyl-2-1-naphthalenyloxy-9h-purin-6-amine, 2-1-napthoxy-6-4-morpholinoanilino-9-cyclohexylpurine, 9-cyclohexyl-n-4-morpholin-4-ylphenyl-2-naphthalen-1-yloxypurin-6-amine
PubChem CID 5284329
ChEBI CHEBI:63053
IUPAC Name 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine
SMILES C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76

Specifica

Materiale o nome chimico Purmorphamine
Quantità 10 mg
Peso formulazione 520.62
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