Thermo Scientific™ Cryptococcus Antigen Test Kit

Descrizione

Rapidly detect capsular polysaccharide antigens associated with Cryptococcus neoformans infection using Thermo Scientific™ Remel™ Cryptococcus Antigen Test Kit. In 1963, Bloomfield reported detection of cryptococcal polysaccharide (CPS) antigens in serum and CSF of patients with cryptococcosis¹. In further testing, investigators reported false-positive reactions in the serum of patients with rheumatoid factor^2,3. In 1983, Stockman and Roberts introduced an enzymatic method incorporating protease to eliminate interference factors in serum⁴.

Cryptococcosis is a systemic infection caused by the yeast, C. neoformans¹. The natural reservoirs for C. neoformans are soil and avian feces. Inhalation of yeast cells may lead to a lung infection and possibly disseminated disease. Patients often present with devastating debilitation, especially those with an immunosuppressive syndrome. Because C. neoformans has an unusual affinity for central nervous system tissue, rapid and early detection is essential.

• Sensitive test
• Rapid test: Results are obtained within 5 minutes.
• Easy to identify: A positive test is indicated by any agglutination or clumping and clearing of the test latex immediately after 5 mins rotation step, whereas a negative test is indicated by no agglutination or clumping.
• Semi-quantitative test: The titer is the reciprocal of the last dilution which produces a positive result (agglutination).

Cryptococcus Antigen Test Kit incorporates the use of latex particles sensitized with murine (mouse) IgM monoclonal antibodies. CPS antigen in patient serum or CSF interacts with sensitized latex particles producing visible agglutination. The use of IgM monoclonal antibodies and treatment of serum with protease reduce the potential for false-positive reactions, eliminating the need to perform a companion control latex test to verify the specificity of results^5-6. This test has both diagnostic and prognostic value since progressive disease is usually accompanied by increasing antigen titers. Declining titers are usually associated with clinical improvement, with or without therapy.

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Remel™ and Oxoid™ products are now part of the Thermo Scientific brand.