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SR 95531 hydrobromide, Tocris Bioscience™

Codice prodotto. 30001219
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Quantità:
10 mg
50 mg
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

Competitive and selective GABAA antagonist

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone -induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.

Identificatori chimici

CAS 104104-50-9
Formula molecolare C15H18BrN3O3
Molecular Weight (g/mol) 368.231
InChI Key GFZHNFOGCMEYTA-UHFFFAOYSA-N
Sinonimo gabazine, sr 95531 hydrobromide, gabazine hydrobromide,sr-95531, 1 6h-pyridazinebutanoic acid, 6-imino-3-4-methoxyphenyl-, monohydrobromide, 4-6-imino-3-4-methoxyphenyl pyridazin-1 6h-yl butanoic acid hydrobromide, 6-amino-5-methyl-3-4-methoxyphenyl-1-pyridaziniumbutyric acid br, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid hydrobromide, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid monohydrobromide, 1 6h-pyridazinebutanoicacid, 6-imino-3-4-methoxyphenyl-, hydrobromide 1:1, gabazine hydrobromide
PubChem CID 107895
IUPAC Name 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
SMILES COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

Specifica

Materiale o nome chimico SR 95531 hydrobromide
Quantità 10 mg
Peso formulazione 368.23
Percent Purity >98%
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