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Tocris Bioscience™ FK 506

Potent calcineurin inhibitor; immunosuppressant

Marque:  Tocris Bioscience™ 3631/10

Code produit. 18756286

  • 275.00€ / 10mg

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Description

Description

FK 506 is a potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Analog also available.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

>99%
10 mg
804.02
Tacrolimus, Fujimycin
FK 506
FK 506
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