Learn More
Thermo Scientific Chemicals Moxifloxacin hydrochloride
Descrizione
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Moxifloxacin hydrochloride is a fourth-generation synthetic fluoroquinolone compound with antibacterial activity against both gram-positive and gram-negative bacteria
• It also shows an inhibitory activity against topoisomerase II
• Moxifloxacin hydrochloride can bind to and inhibit both bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in DNA replication and repair inhibition thus induce cell death in sensitive bacterial species
• Moxifloxacin has 100 times higher affinity for bacterial DNA gyrase compared to mammalian DNA gyrase
Applications
• Moxifloxacin hydrochloride presents a higher anti-gram-positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin
• It has immunosuppressive activity that inhibits the proliferation of all classes of lymphocytes, which can induce apoptosis of antigen-presenting T cells
• It is a cytostatic anthracenedione that can intercalate DNA, increasing the occurence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA
• This compound shows anticancer activity in some animal models presenting leukemia
• Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis strains
Specifica
Specifica
| Materiale o nome chimico | Moxifloxacin hydrochloride |
| Tipo | Moxifloxacin Hydrochloride |
| CAS | 186826-86-8 |
| Punto di fusione | 324.0°C to 325.0°C |
| Spettro a infrarossi | Authentic |
| Acqua | 5% max. |
| Quantità | 1 g |
| Formula molecolare | C21H25ClFN3O4 |
| InChI Key | IDIIJJHBXUESQI-DFIJPDEKSA-N |
| SMILES | COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl |
| Vedi altri risultati |
Sicurezza e movimentazione
- Moxifloxacin hydrochloride
- Attenzione
- Tossicità acuta Categoria 4
- PERICOLO A LUNGO TERMINE PER L'AMBIENTE ACQUATICO Cronico 3
- Lesione oculare grave/irritazione oculare Categoria 2
- H302-Nocivo se ingerito.
- H319-Provoca grave irritazione oculare.
- H412-Nocivo per gli organismi acquatici con effetti di lunga durata.
- P264-Lavare accuratamente dopo l'uso.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P301+P330+P331-IN CASO DI INGESTIONE: sciacquare la bocca. NON provocare il vomito.
- P305+P351+P338-IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.
- P312-Contattare un CENTRO ANTIVELENI/un medico/in caso di malessere.
- MIXTURE LIST-Contiene: Moxifloxacin hydrochloride
RUO – Research Use Only
Fornite il vostro feedback sul contenuto del prodotto compilando il modulo sottostante.