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Rapamycin, 98+%, Thermo Scientific Chemicals
Descrizione
Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell proliferation and suppressing tumor angiogenesis. It forms a complex with FKBP12 that binds and inhibits the molecular target of rapamycin (mTOR) as well as suppresses the immune system, preventing transplant rejection.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
- Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin’s molecular target (rapamycin kinase)
Application
- Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
- This compound also blocks cytokine-mediated signal transduction pathways
- Rapamycin also promotes the suppression of the immune system
- It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
- In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling
Specifica
Specifica
| Materiale o nome chimico | Rapamycin |
| Tipo | Rapamycin |
| Forma fisica | Powder |
| Colore | White |
| Quantità | 100 mg |
| Indice di Merck | 14,8114 |
| Informazioni di solubilità | Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in water. |
| Peso formulazione | 914.17 |
| Percent Purity | ≥99% |
Sicurezza e movimentazione
- Pericolo
- cancerogenicità Categoria 2
- Tossicità per la riproduzione Categoria 2
- Tossicità specifica per organi bersaglio (esposizione ripetuta) Categoria 1
- H351-Sospettato di provocare il cancro.
- H361-Sospettato di nuocere alla fertilità o al feto.
- H372-Provoca danni agli organi.
- P201-Procurarsi istruzioni specifiche prima dell'uso.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
RUO – Research Use Only
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