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Tocris Bioscience™ ZLN 024 hydrochloride
Allosteric AMPK activator
225.70€ - 781.84€
Specifica
| Materiale o nome chimico | 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride |
|---|---|
| Bersaglio | AMPK Activators |
| Formula molecolare | C13H13BrN2OS.HCl |
| Peso formulazione | 361.69 |
| Purezza | >99% |
Descrizione
ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.Specifica
| 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride | |
| C13H13BrN2OS.HCl | |
| >99% |
| AMPK Activators | |
| 361.69 |
Sicurezza e movimentazione
Recommended Storage : Store at 4°C
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Titolo del prodotto
Tocris Bioscience™ ZLN 024 hydrochloride